Table 2.

Model 1, multinomial logistic regressions showing associations of class membership¹ with familial risk factors (father’s 4-group design variable indicating levels of genetic and environmental risk, paternal and maternal substance use and psychiatric disorders and sibling problem substance use) adjusted for offspring demographics¹

	Class 2 AUD²	Class 3 AUD-MDD-ANX³	Class 4 SUD-CD⁴

	OR (95% CI)	OR (95% CI)	OR (95% CI)
Familial risk factors
Father’s 4-group design
Group 1, HG & HE	1.63 (1.02–2.59)	1.25 (0.61–2.57)	2.18 (0.82–5.75)
Group 2, HG & LE	1.44 (0.68–3.08)	0.45 (0.11–1.84)	1.28 (0.31–5.27)
Group 3, MG & LE	1.20 (0.64–2.25)	0.58 (0.17–1.96)	1.42 (0.34–5.91)
Group 4, LG & LE	1.0	1.0	1.0
Maternal marijuana abuse/ dependence	1.10 (0.53–2.30)	0.51 (0.14–1.82)	1.66 (0.60–4.55)
Father current or former smoker	1.39 (0.92–2.12)	1.33 (0.67–2.66)	1.12 (0.54–2.29)
Paternal externalizing disorder	1.01 (0.61–1.66)	1.04 (0.48–2.24)	2.22 (1.04–4.76)
Maternal depression	1.61 (1.04–2.48)	3.50 (1.87–6.55)	1.92 (0.97–3.79)
Sibling alcohol problems	1.01 (0.63–1.63)	2.42 (1.26–4.64)	1.07 (0.50–2.31)
Sibling drug use
Marijuana or other drug only	1.90 (1.27–2.85)	1.34 (0.67–2.66)	1.58 (0.70–3.58)
Marijuana and other drugs	3.94 (2.48–6.27)	3.37 (1.72–6.58)	6.91 (3.20–14.92)

Demographics
Male gender	2.50 (1.80–3.47)	1.06 (0.61–1.84)	4.09 (2.18–7.65)
Age 18 and older	8.45 (4.28–16.68)	3.24 (1.20–8.76)	7.67 (1.59–37.07)
Non-Caucasian	0.98 (0.62–1.55)	0.79 (0.32–1.91)	0.29 (0.07–1.26)

Class 1 is reference group; model adjusted for missing data on mothers and siblings,

AUD = alcohol abuse/dependence.

AUD-MDD-ANX = alcohol abuse/dependence, major depressive disorder and any anxiety disorder (social phobia, panic disorder, generalized anxiety disorder).

⁴

SUD – CD = alcohol abuse/dependence, marijuana abuse/dependence, nicotine dependence and conduct disorder.

Bold text = statistically significant odds ratios.