Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2013 Nov 1.

Published in final edited form as: Neuromodulation. 2012 Jul 2;15(6):508–519. doi: 10.1111/j.1525-1403.2012.00479.x

Table 2.

Summary of Ziconotide PK following Bolus Intravenous Administration (0.1 mg/kg)

PK Paramete	Statistics	Ziconoti
PK Paramete	Statistics	Plas	CS
	N	5	4
C₀ (ng/mL)	Median	9	N
C₀ (ng/mL)	Range	419 – 1138	N
C_max (ng/mL)	Median	6	20
C_max (ng/mL)	Range	428 –	6.6 –
T_max (h)	Median	0.	0.
T_max (h)	Range	0.03 – 0.08	0.
T_½-β (h)	Median	1.	1.
T_½-β (h)	Range	1.06 – 1.43	0.95 –
AUC_∞ (ng·h/mL)	Median	2	38
AUC_∞ (ng·h/mL)	Range	185 –	15.9 –
CL^a or CL/F^b (mL/h)	Median	628	4256
CL^a or CL/F^b (mL/h)	Range	3027 – 8613^a	22184 – 91574^b
V ^a or V /F^b z z (mL)	Median	1264	102615
V ^a or V /F^b z z (mL)	Range	4618 – 17786^a	30436 – 243703^b
V_ss (mL)	Median	23	N
V_ss (mL)	Range	1979 – 7840	N

NA = not applicable.