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. 2012 Dec;22(12):2427–2435. doi: 10.1101/gr.131953.111

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© 2012, Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported License), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 2. — Retained network patterns in a paired gene cluster after gene and/or PPI losses. Rectangles and horizontal lines represent genes and chromosomes, respectively. Red and green lines indicate cis- and trans-PPIs, respectively. (White rectangles) Genes before they experienced WGD. Blue and black rectangles show extant-paired ohnologs and singletons, respectively. Pink and blue arrows indicate PPI losses and gains during evolution, respectively. All possible scenarios that retain at least one PPI are shown.