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. Author manuscript; available in PMC: 2013 Dec 15.
Published in final edited form as: Vision Res. 2012 Sep 19;75:26–32. doi: 10.1016/j.visres.2012.08.012

Figure 6.

Figure 6

Model of src-TK activation by UNC119A. A, UNC119 sequence with locations of SH2- and SH3-interacting domains (ID, red) (Cen et al., 2003). Two SH2-IDs are located in the N-terminal region, one SH3-ID is located on β7. The tyrosine phosphorylation site (green) on β5 is shown. B, Depiction of inhibited Src-type tyrosine kinase (left) and its activation by Unc119A (right) (adapted from (Xu et al., 1999). In the inhibited form, Y527 is phosphorylated and interacts with SH2; the loop forms an inhibitory helix. In the active form, kinase domains are displaced by UNC119’s SH2- and SH3-IDs, allowing phosphorylation of Y416 and activation.