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. 2012 Dec 4;3:456. doi: 10.3389/fphys.2012.00456

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Copyright © 2012 Domnik, Seaborn, Vincent, Akl, Redfearn and Fisher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Heart rate variability prior to and during aerosol challenge. The acclimation control period (0–60 min) and aerosol challenge (70–130 min, to accommodate sampling) were independently analyzed by Two-Way ANOVA and Holm-Sidak post-hoc analyses; ^*P < 0.05. During acclimation, OVA-sensitized mice displayed decreased SDNN (P < 0.05), LF (P < 0.025), and LF/HF (P < 0.05) compared with Alum control mice. During aerosolized Ag challenge, RMMSD (P < 0.05) and pNN6 (P < 0.05) were significantly increased in OVA-sensitized mice compared to the Alum controls.