Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Dec;140(6):625–634. doi: 10.1085/jgp.201210849

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 Horrigan

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 3. — The energetics of voltage sensor/gate coupling. (A) Voltage sensor/gate states in a single subunit. Numbers refer to data in B, C, and D used to determine the indicated equilibrium constants. (B) P_O-V determines L (1) and LD⁴ (2). Dashed lines indicate the predicted voltage dependence of P_O with all voltage sensors either in the resting or activated state and z_L = 0.3 e. (C) Normalized Q_C-V for closed channels determined from ON gating currents (inset) is fit by a Boltzmann function with z_J = 0.58 e and defines J (3). (D) Q_O-V relation for open channels defines JD (4). Q_O is estimated by fitting the foot of the q_a-V relation (q_a = kTdln(P_O)/dV) with a Boltzmann function. The shift between Q_O and Q_C relations defines the coupling factor D.