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. 2012 Dec;140(6):599–612. doi: 10.1085/jgp.201210844

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© 2012 Colquhon and Lapè

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — Classical mechanisms. (A) The mechanism proposed by Del Castillo and Katz (1957): the first explicit separation of binding and gating. (B) A typical example of the type of mechanism used to describe the nicotinic receptor, with two subunits, and monoliganded openings as well diliganded. (C) The MWC mechanism. All three models postulate the existence of only two conformations of the channel protein, shut (black) and open (red).