Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Dec;140(6):599–612. doi: 10.1085/jgp.201210844

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 Colquhon and Lapè

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 2. — A mechanism that can fit results with heteromeric glycine receptors. A Jones-Westbrook type of mechanism adapted for the heteromeric glycine receptor, with three binding sites. Three extra shut states are postulated, distal to open states (red). Although they are denoted as the D conformation (green), they bear no obvious relationship to macroscopic desensitization in this case. Rate constants are marked in black for each transition, and equilibrium constants are marked in brown. The values are means of fits to three sets of data, taken from Table 4 of Burzomato et al. (2004). Note that equilibrium constants for each set were averaged, rather than calculated from the averaged rate constants. Therefore, the ratio of the mean rate constants will not generally be the same as the mean equilibrium constant, especially when the scatter between sets is large (e.g., for D₁).