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. 2012 Dec;140(6):697–716. doi: 10.1085/jgp.201210804

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© 2012 Vais et al.

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Figure 3. — Modulation of InsP₃R channel activity by various [Ca²⁺]_ER in saturating [InsP₃]. (A) A typical single-channel current trace recorded during a switch of [Ca²⁺]_ER from 70 nM to 1.1 mM. Note the substantially smaller channel current when [Ca²⁺]_ER = 1.1 mM as a result of the blocking of the channel by permeant Ca²⁺. A part of the current trace (indicated by an orange line) is shown with larger current and time scales in the inset to show the details of channel gating in [Ca²⁺]_ER = 1.1 mM. (B–D) Bar graphs of mean ratios of channel P_o, t_o, and t_c observed before and after [Ca²⁺]_ER switches between 70 nM and 300 µM or 1.1 mM, as indicated.