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. 2012 Dec;140(6):697–716. doi: 10.1085/jgp.201210804

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© 2012 Vais et al.

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Figure 9. — Abrogation of activation of InsP₃R-3 channel activity by physiological levels of [Ca²⁺]_ER. (A–C) Typical single-current traces recorded during a switch of [Ca²⁺]_ER from 70 nM to 550 µM with different V_app used. (D–F) Bar graphs of mean ratios of channel P_o, t_o, and t_c observed before and after [Ca²⁺]_ER switches between 70 nM and 550 µM, showing the abrogation of activating effects of 550 µM [Ca²⁺]_ER on InsP₃R channel activity by increasing positive V_app and strong cytoplasmic Ca²⁺ buffering used. ^ooo and ^oo indicate statistically significant difference between the two ratios connected by the bracket (P < 0.005 and 0.01, respectively; unpaired t test). Note the logarithmic scale used for the t_o axis (in red) in E.