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. 2012 Nov;14(11):1057–1066. doi: 10.1593/neo.12736

Figure 5.

Figure 5

Human AML cells fuse also with dendritic and endothelial cells. (A) Upper panels show flow cytometry analysis of cells coexpressing human CD45, CD33, and CD14 that express also murine CD11c, a dendritic cell-specific marker. Lower panels show flow cytometry analysis of mouse endothelial cells (Flk-1-positive) expressing human CD45 and human CD31. (B) In addition to AML, ALL cell transplantation induces cell fusion in vivo; 1 x 107 primary human ALL cells were injected ip, and 47 α 6 (ALL-B) or 72 ± 13 (ALL-T) days later, animals were sacrificed and spleen cells were analyzed by flow cytometry for the co-expression of human and mouse CD45. (C) Human CD45 and mouse CD45 flow cytometry expression patterns of BM cells from a primary and a secondary recipient of human cord blood CD34+ cells showing absence of hybrid cells.