Table 2.
Extracellular noradrenaline and dopamine numerical concentrations in the frontal cortex and striatum
| FC | STR | |||
|---|---|---|---|---|
| NA | DA | NA | DA | |
| Shams | 3.51 ± 0.34 | 4.55 ± 0.41 | 5.73 ± 0.26 | 22.83 ± 0.44 |
| 6-OHDA | 3.65 ± 0.25 | 2.14 ± 0.35** | 5.91 ± 0.33 | 12.33 ± 0.47** |
| DSP-4 | 1.16 ± 0.27** | 4.73 ± 0.38 | 2.40 ± 0.48** | 23.89 ± 0.52 |
| EX-4 | 3.75 ± 0.19 | 4.79 ± 0.50 | 5.87 ± 0.23 | 23.11 ± 0.39 |
| 6-OHDA + DSP-4 | 1.19 ± 0.22** | 0.98 ± 0.47+ | 2.96 ± 0.28** | 8.95 ± 0.48+ |
| 6-OHDA + DSP-4 + EX-4 | 3.83 ± 0.30 | 5.01 ± 0.55 | 5.75 ± 0.31 | 22.80 ± 0.50 |
All values are expressed as mean ± SEM denoted in fmol 10µl−1. All results were analysed using two-way anova and a post hoc Bonferroni's test to compare differences between groups (n= 10).
* Indicates different from sham, P < 0.05;
**
indicates different from sham P < 0.001;
+
indicates different from 6-OHDA only, P < 0.05.
FC, frontal cortex; STR, striatum.