Figure 3.

Correlations of the drug-induced inhibition of ACh-induced gamma power with the drug-receptor pK_i values. The normalized inhibition of peak power (1 – peak power norm.) of ACh-induced gamma oscillations by the antipsychotics amisulpride (AMS), chlorprothixene (CPT), clozapine (CZP), flupenthixol (FLP), haloperidol (HAL), risperidone (RSP) and ziprasidone (ZPS) was plotted against the pK_i values of these drugs for 19 receptors, among them the 5-HT₃ (A) and the D₃ receptor (B), and analysed for correlation. Chlorpromazine was excluded from the analysis because it was the only antipsychotic drug that enhanced the peak power. (C) The correlation index r² is shown for each receptor. (D) The slope of the regression line is shown for each receptor. 5-HT_2A-D₂ indicates the difference in pK_i values between the 5-HT_2A and D₂ receptors. Bars to the left indicate a negative correlation, bars to the right a positive correlation. *P < 0.05 (C, D).