Figure 8.

LV systolic and diastolic function. Ischaemia/reperfusion caused a significant reduction in cardiac systolic function measured by echocardiography (A) over the 42 days of reperfusion. Relative to these values in the control group, curcumin treatment significantly preserved cardiac systolic function; measured as FS, fraction shortening; SV, stroke volume; EF, ejection fraction. Cardiac diastolic function was measured by a pulsed-wave Doppler spectra of mitral inflow from the apical four-chamber view, that is, a ratio of early diastolic filling (E-wave) velocity and atrial filling (A-wave) velocity (panel B). Relative to the control, curcumin significantly preserved the E : A ratio over time. n= 8, values are mean ± SEM. *P < 0.05 versus baseline values in the sham and control group; †P < 0.05 versus control.