Skip to main content
. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Nutr Rev. 2012 Oct 12;70(12):721–729. doi: 10.1111/j.1753-4887.2012.00522.x

Figure 2. Low VDR expression in Colon Cancer: a Genomic Explanation.

Figure 2

(A) SNAIL1 is a zinc-finger transcription factor that binds to the VDR gene promoter and represses activity and therefore decreases VDR mRNA expression levels. (B) ZEB1 and 2 are transcription factors that can dimerize and bind to the VDR promoter region and activate or repress the transcription of VDR mRNA depending on the presence of co-factors, such as p300 and CtBP.