Figure 2. Low VDR expression in Colon Cancer: a Genomic Explanation.
(A) SNAIL1 is a zinc-finger transcription factor that binds to the VDR gene promoter and represses activity and therefore decreases VDR mRNA expression levels. (B) ZEB1 and 2 are transcription factors that can dimerize and bind to the VDR promoter region and activate or repress the transcription of VDR mRNA depending on the presence of co-factors, such as p300 and CtBP.