. 2012 Nov 22;2012:195367. doi: 10.1155/2012/195367

Table 2.

Effect of OPLE on renal functional parameters.

	Nondiabetic	Diabetic control	Diabetic + OPLE	Diabetic + OPLE
	Nondiabetic	Diabetic control	200 mg kg⁻¹	500 mg kg⁻¹
	(4 week)	(4 week)	(4 week)	(4 week)
	(12 week)	(12 week)	(12 week)	(12 week)
Renal blood flow mL min⁻¹ g⁻¹ kidney	1.43 ± 0.10	2.27 ± 0.39	1.72 ± 0.26	1.80 ± 0.03
Renal blood flow mL min⁻¹ g⁻¹ kidney	1.66 ± 0.14	2.49 ± 0.16^aaa	1.78 ± 0.06^bb	1.47 ± 0.05^bbb
Glomerular filtration rate mL min⁻¹ g⁻¹ kidney	0.61 ± 0.06	0.96 ± 0.04^aa	0.67 ± 0.07^b	0.63 ± 0.09^b
Glomerular filtration rate mL min⁻¹ g⁻¹ kidney	0.50 ± 0.05	0.84 ± 0.06^aa	0.75 ± 0.06^a	0.58 ± 0.02^b
Urine flow rate μL min⁻¹ g⁻¹ kidney	3.75 ± 0.59	10.68 ± 1.30^aaa	5.27 ± 0.45^bb	5.80 ± 0.80^bb
Urine flow rate μL min⁻¹ g⁻¹ kidney	2.89 ± 0.34	7.84 ± 0.70^aaa	6.42 ± 0.50^aa	5.29 ± 0.70^a,b
Urinary protein excretion mg 2 h⁻¹	1.33 ± 0.03	6.83 ± 0.30^aaa	2.87 ± 0.17^a,bbb	1.89 ± 0.34^bbb
Urinary protein excretion mg 2 h⁻¹	1.13 ± 0.05	4.66 ± 0.73^aaa	2.92 ± 0 .26^a,b	2.68 ± 0.21^a,bb
Fractional sodium excretion %	0.63 ± 0.19	1.34 ± 0.34	0.96 ± 0.22	0.90 ± 0.17
Fractional sodium excretion %	0.56 ± 0.08	1.08 ± 0.23	0.76 ± 0.24	0.79 ± 0.23

Data are expressed as mean ± SEM of six experiments for each group. ^a P < 0.05; ^aa P < 0.01; ^aaa P < 0.001 versus corresponding nondiabetic; ^b P < 0.05; ^bb P < 0.01; ^bbb P < 0.001 versus corresponding diabetic control.