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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Hypertension. 2012 Jul 16;60(3):691–696. doi: 10.1161/HYPERTENSIONAHA.112.193045

Figure 4.

Figure 4

Enhanced responses of mean arterial pressure (MAP) and heart rate (HR) to icv infusion of Na-rich aCSF (235 mM Na) in Nedd4-2 −/− mice are prevented by icv benzamil. Groups of W/T or −/− mice (n=5-6) received icv vehicle in aCSF and Na-rich aCSF, while other groups (n=5-6) received the same two solutions containing benzamil (7.4 ng/min). Values represent the mean ± SEM of the change from baseline. Baseline MAP and HR prior to infusion of aCSF were: 124 ± 5 mmHg, 490 ± 39 b/min and 119 ± 7 mmHg, 507 ± 7 b/min for −/ − and W/T mice receiving icv vehicle vs. 127 ± 6 mmHg, 440 ± 20 b/min and 117 ± 6 mmHg, 480 ± 236 b/min for the respective benzamil groups.

* p = 0.0015 vs other 3 groups

a p < 0.05 for treatment effect (vehicle vs benzamil)