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Total (secreted plus intracellular) GABA levels (a–c) and total (secreted plus intracellular) adrenaline levels (d–f) in HPDE6-C7, BxPC-3 and Panc-1 cells treated with single doses of nicotine from 10 pM through 10 µM for 30min or pretreated with 1 µM nicotine for 7 days and then exposed to identical concentrations of nicotine. Data points are mean and ±SD from five samples per treatment group.
