Table I.
Host characteristics of the discovery and replication populations
| Discovery | Replication | |||
|---|---|---|---|---|
| Cases, n(%) | Controls, n(%) | Cases, n(%) | Controls, n(%) | |
| N = 661 | N = 959 | N = 1154 | N = 1073 | |
| Age, mean(SD) | 62.43 (11.63) | 64.52 (11.13) | 62.08 (10.78) | 60.48 (8.75) |
| Sex, N(%) | ||||
| Male | 299 (45.23) | 775 (80.81) | 658 (57.02) | 581 (54.15) |
| Female | 362 (54.77) | 184 (19.19) | 496 (42.98) | 492 (45.85) |
| Smoking status, N(%) | ||||
| Never smoker | 328 (49.62) | 408 (42.54) | 0 (0%) | 0 (0%) |
| Former smoker | 183 (27.69) | 475 (49.53) | 600 (51.99) | 595 (55.45) |
| Current smoker | 150 (22.69) | 76 (7.92) | 554 (48.01) | 478 (44.45) |
| Pack year of smoking, mean (SD) | 50.59 (32.48) | 32.51 (29.38) | 51.49 (31.41) | 44.45 (29.90) |
| Asbestos exposure, N(%) | ||||
| Yes | 212 (32.07) | 87 (9.07) | 368 (31.89) | 243 (22.65) |
| No | 416 (62.93) | 864 (90.09) | 754 (65.34) | 826 (76.98) |
| Unknown or not available | 33 (4.99) | 8 (0.83) | 32 (2.77) | 4 (0.37) |
| Hay fever, N(%) | ||||
| Yes | 107 (16.19) | N/A | 173 (14.99) | 238 (22.18) |
| No | 517 (78.21) | N/A | 957 (82.93) | 834 (77.73) |
| Unknown or not available | 37 (5.60) | N/A | 24 (2.08) | 1 (0.09) |
| Lung cancer in first-degree relatives, N(%) | ||||
| Yes | 191 (28.90) | 202 (21.06) | 280 (24.26) | 180 (16.78) |
| No | 470 (71.10) | 755 (78.73) | 874 (75.74) | 893 (83.22) |
| Unknown or not available | 0(0.00) | 2(0.21) | 0(0.00) | 0(0.00) |
| Histology, N(%) | ||||
| Adenocarcinoma | 408 (61.72) | 543 (47.05) | ||
| Squamous cell carcinoma | 119 (18.00) | 285 (24.70) | ||
| Large cell carcinoma | 8 (1.21) | 39 (3.38) | ||
| Adenosquamous carcinoma | 4 (0.61) | 11 (0.95) | ||
| Bronchioloalveolar carcinoma | 21 (3.18) | 26 (2.25) | ||
| Non-small cell carcinoma, NOS | 93 (14.07) | 174 (15.08) | ||
| Carcinomas with other features | 8(1.21) | 76(6.59) | ||
| Clinical stage, N(%) | ||||
| IA | 54 (8.17) | 155 (13.43) | ||
| IB | 38 (5.75) | 141 (12.22) | ||
| IIA | 2 (0.30) | 18 (1.56) | ||
| IIB | 13 (1.97) | 76 (6.59) | ||
| IIIA | 127 (19.21) | 172 (14.90) | ||
| IIIB dry | 100 (15.13) | 156 (13.52) | ||
| IIIB wet | 27 (4.08) | 41 (3.55) | ||
| IV | 300 (45.39) | 395 (34.23) | ||
| Grade, N(%) | ||||
| Well differentiated | 48 (7.26) | 56 (4.85) | ||
| Moderately differentiated | 154 (23.30) | 248 (21.49) | ||
| Poorly differentiated | 234 (35.40) | 524 (45.41) | ||
| Undifferentiated | 6 (0.91) | 15 (1.30) | ||
| Unknown or not available | 219 (33.13) | 311 (26.95) | ||