Table II.
SNPs significantly associated with lung cancer risk in the discovery population
| Gene | SNP id | Minor allele | Casesa | Controlsa | Genetic model | Adjusted OR b | P value |
|---|---|---|---|---|---|---|---|
| ANKS1B | rs10459194 | g | 310\295\50 | 439\406\114 | Recessive | 0.50 (0.32–0.77) | 0.002 |
| ANKS1B | rs10745877 | g | 281\287\93 | 431\436\92 | Recessive | 1.60 (1.08–2.36) | 0.019 |
| ANKS1B | rs11109966 | a | 249\341\71 | 415\424\120 | Dominant | 1.37 (1.06–1.78) | 0.017 |
| ANKS1B | rs11110099 | c | 183\330\147 | 311\471\176 | Additive | 1.19 (0.99–1.43) | 0.057 |
| ANKS1B | rs1403506 | g | 418\224\19 | 561\344\54 | Additive | 0.72 (0.58–0.89) | 0.003 |
| ANKS1B | rs1523097 | g | 237\340\84 | 324\456\179 | Recessive | 0.55 (0.39–0.78) | <0.001 |
| ANKS1B | rs1549102 | c | 195\341\125 | 274\456\229 | Additive | 0.80 (0.67–0.96) | 0.015 |
| ANKS1B | rs201363 | a | 474\174\13 | 749\195\15 | Dominant | 1.50 (1.12–2.01) | 0.006 |
| ANKS1B | rs4762543 | a | 244\335\82 | 333\449\177 | Recessive | 0.56 (0.39–0.79) | 0.001 |
| ANKS1B | rs7135384 | g | 192\346\123 | 335\450\174 | Dominant | 1.49 (1.13–1.96) | 0.005 |
| ANKS1B | rs7139028 | a | 236\347\78 | 339\445\175 | Recessive | 0.53 (0.37–0.76) | <0.001 |
| ANKS1B | rs7301050 | a | 432\209\20 | 576\334\49 | Additive | 0.72 (0.57–0.89) | 0.003 |
| ANKS1B | rs7959046 | a | 421\217\23 | 554\348\57 | Additive | 0.71 (0.57–0.88) | 0.002 |
| ANKS1B | rs7963120 | g | 541\112\7 | 758\187\14 | Dominant | 0.63 (0.45–0.87) | 0.005 |
| ANKS1B | rs869032 | a | 418\220\23 | 554\348\57 | Additive | 0.72 (0.58–0.89) | 0.003 |
| Bcl-2 | rs12454650 | g | 323\294\44 | 526\357\76 | Dominant | 1.28 (1.00–1.65) | 0.05 |
| Bcl-2 | rs12454712 | g | 230\339\91 | 392\444\121 | Dominant | 1.42 (1.09–1.85) | 0.009 |
| Bcl-2 | rs1462129 | a | 175\335\151 | 288\472\199 | Additive | 1.30 (1.08–1.55) | 0.005 |
| Bcl-2 | rs1982673 | c | 459\185\17 | 707\228\24 | Dominant | 1.28 (1.02–1.69) | 0.034 |
| Bcl-2 | rs7243091 | a | 409\212\38 | 561\358\39 | Dominant | 0.78 (0.60–0.99) | 0.04 |
| Bcl-2 | rs8098848 | g | 319\295\47 | 522\359\78 | Dominant | 1.28 (1.00–1.65) | 0.05 |
| Bcl-2 | rs2255302 | g | 315\309\37 | 540\355\64 | Dominant | 1.69 (1.31–2.18) | <0.001 |
| Bcl-2 | rs2551402 | a | 158\344\159 | 263\480\216 | Additive | 1.30 (1.08–1.55) | 0.005 |
| Bcl-2 | rs2849371 | a | 315\309\37 | 534\360\65 | Dominant | 1.62 (1.26–2.09) | <0.001 |
| Bcl-2 | rs2849372 | g | 314\310\37 | 534\360\65 | Dominant | 1.62 (1.26–2.09) | <0.001 |
| Bcl-2 | rs2850767 | c | 263\317\81 | 425\427\107 | Dominant | 1.31 (1.01–1.69) | 0.04 |
| BID | rs366542 | g | 165\332\164 | 280\458\221 | Dominant | 1.31 (1.00–1.75) | 0.05 |
| BMF | rs11858141 | g | 233\332\96 | 285\492\182 | Additive | 0.78 (0.65–0.94) | 0.008 |
| BMF | rs16970325 | a | 531\122\8 | 816\138\5 | Dominant | 1.35 (1.00–1.88) | 0.05 |
| BMF | rs500804 | a | 293\300\68 | 515\366\78 | Dominant | 1.49 (1.15–1.92) | 0.002 |
| BMF | rs537455 | c | 332\272\54 | 552\337\70 | Dominant | 1.49 (1.16–1.92) | 0.002 |
| CAPN2 | rs12080565 | a | 602\57\2 | 850\103\5 | Dominant | 0.75 (0.49–0.97) | 0.035 |
| CAPN2 | rs1222145 | c | 396\242\23 | 564\333\61 | Recessive | 0.51 (0.30–0.88) | 0.014 |
| CAPN2 | rs16842040 | a | 630\31\0 | 891\65\3 | Dominant | 0.59 (0.34–0.99) | 0.049 |
| CASP3 | rs2019978 | c | 408\228\25 | 624\300\35 | Dominant | 1.29 (1.02–1.67) | 0.03 |
| CASP8 | rs3769823 | a | 312\295\54 | 507\378\74 | Dominant | 1.37 (1.06–1.76) | 0.014 |
| CASP9 | rs4645989 | g | 311\277\72 | 490\384\83 | Recessive | 1.48 (1.02–2.24) | 0.038 |
| CASP9 | rs6685648 | g | 312\277\72 | 489\388\82 | Additive | 1.17 (0.97–1.429) | 0.102 |
| CFLAR | rs4487072 | a | 437\196\28 | 583\346\30 | Dominant | 0.79 (0.61–1.00) | 0.049 |
| CFLAR | rs7583529 | a | 442\191\28 | 588\334\36 | Dominant | 0.81 (0.62–1.00) | 0.049 |
| CASP2 | rs17164250 | a | 404\212\44 | 606\308\43 | Recessive | 2.13 (1.24–6.67) | 0.006 |
| CASP2 | rs2272256 | a | 371\258\31 | 539\353\67 | Recessive | 0.62 (0.35–0.99) | 0.044 |
| DAXX | rs2239839 | a | 346\269\45 | 470\389\100 | Recessive | 0.59 (0.37–0.93) | 0.02 |
| DAXX | rs2282851 | a | 347\269\45 | 469\390\100 | Recessive | 0.58 (0.37–0.92) | 0.02 |
| FADD | rs10898847 | a | 206\335\120 | 346\465\148 | Dominant | 1.30 (1.03–1.64) | 0.03 |
| FAS | rs2147419 | c | 345\259\57 | 451\422\86 | Dominant | 0.79 (0.61–1.01) | 0.06 |
| FOXO1A | rs17630266 | a | 600\58\2 | 902\55\2 | Dominant | 1.75 (1.09–2.80) | 0.02 |
| BAX | rs1042265 | a | 535\117\9 | 813\140\6 | Dominant | 1.53 (1.10–2.12) | 0.011 |
| BAX | rs2270937 | a | 274\315\72 | 445\419\95 | Dominant | 1.29 (1.00–1.67) | 0.049 |
| NCR3 | rs2844480 | a | 406\224\31 | 632\284\43 | Dominant | 1.46 (1.12–1.90) | 0.005 |
| TNFRSF10A | rs2230229 | g | 498\149\14 | 690\241\28 | Dominant | 0.67 (0.50–0.89) | 0.007 |
| TNFRSF10D | rs3924519 | g | 365\252\44 | 474\409\76 | Additive | 0.81 (0.66–0.99) | 0.04 |
| TNFRSF1A | rs2228576 | a | 293\310\58 | 401\437\121 | Recessive | 0.72 (0.49–1.01) | 0.06 |
| TNFRSF21 | rs2236037 | a | 518\134\9 | 774\178\7 | Dominant | 1.35 (1.00–1.85) | 0.049 |
| TRAF2 | rs2811761 | g | 375\245\39 | 613\309\36 | Additive | 1.29 (1.04–1.60) | 0.02 |
aThe number of subjects of the WW (wild-type), WM (heterozygous) and MM (homozygous variant) genotypes: WW\WM\MM.
bAdjusted for age, gender, smoking status, pack year of smoking, asbestos exposure and lung cancer in first-degree relatives.