Table IV.
Number of unfavorable genotypes and lung cancer risk
| Cases, n(%) | Controls, n(%) | OR a (95% CI) | P value | |
|---|---|---|---|---|
| Discovery | ||||
| 0 | 20 (3.03) | 64 (6.68) | Ref. | |
| 1 | 177 (26.82) | 279 (29.12) | 2.22 (1.08–4.57) | 0.03 |
| 2 | 266 (40.30) | 409 (42.69) | 2.70 (1.33–5.49) | 0.006 |
| ≥3 | 197 (29.85) | 206 (21.50) | 4.13 (2.00–8.52) | 0.0001 |
| P trend | 6.05E-06 | |||
| Replication | ||||
| 0 | 38 (3.32) | 50 (4.72) | Ref. | |
| 1 | 294 (25.70) | 327 (30.85) | 1.26 (0.78–2.01) | 0.343 |
| 2 | 513 (44.84) | 477 (45.00) | 1.57 (0.99–2.48) | 0.056 |
| ≥3 | 299 (26.14) | 206 (19.43) | 2.13 (1.32–3.44) | 0.002 |
| P trend | 4.36E-06 | |||
| Pooled | ||||
| 0 | 58 (3.22) | 114 (5.65) | Ref. | |
| 1 | 471 (26.11) | 606 (30.03) | 1.61 (1.11–2.34) | 0.01 |
| 2 | 779 (43.18) | 886 (43.90) | 1.87 (1.30–2.69) | 0.0008 |
| ≥3 | 496 (27.49) | 412 (20.42) | 2.72 (1.87–3.97) | 1.89E-07 |
| P trend | 1.41E-10 |
Significant ORs in boldface.
aAdjusted for age, gender, smoking status, pack year of smoking, asbestos exposure, lung cancer in first-degree relatives, prior history of emphysema and hay fever where appropriate.