Table V.
Haplotype association with lung cancer risk
| Haplotype | Cases, n(%) | Controls, n(%) | OR a (95% CI) | P value |
|---|---|---|---|---|
| Bcl-2 (rs1462129-rs2551402) | ||||
| Discovery | ||||
| T_C | 643 (48.64) | 988 (51.51) | Ref. | |
| T_A | 42 (3.18) | 60 (3.13) | 1.27 (0.76–2.12) | 0.365 |
| C_C | 17 (1.29) | 18 (0.94) | 1.56 (0.68–3.60) | 0.297 |
| C_A | 620 (46.90) | 852 (44.42) | 1.31 (1.09–1.57) | 0.0040 |
| Replication | ||||
| T_C | 1104 (48.34) | 1078 (50.61) | Ref. | |
| T_A | 59 (2.58) | 71 (3.33) | 0.82 (0.57–1.19) | 0.298 |
| C_C | 21 (0.92) | 24 (1.13) | 0.82 (0.44–1.53) | 0.540 |
| C_A | 1100 (48.16) | 957 (44.93) | 1.12 (0.98–1.27) | 0.085 |
| Pooled | ||||
| T_C | 1747 (48.45) | 2066 (51.04) | Ref. | |
| T_A | 101 (2.80) | 131 (3.24) | 0.98 (0.73–1.30) | 0.879 |
| C_C | 38 (1.05) | 42 (1.04) | 1.06 (0.66–1.70) | 0.821 |
| C_A | 1720 (47.70) | 1809 (44.69) | 1.17 (1.06–1.30) | 0.001 |
| ANKS1B (rs1549102-rs10745877-rs11110099) | ||||
| Discovery | ||||
| A_A_A | 299 (33.00) | 459 (33.31) | Ref. | |
| A_A_C | 43 (4.75) | 60 (4.35) | 0.84 (0.49–1.44) | 0.518 |
| A_G_A | 1 (0.11) | 1 (0.07) | 2.63 (0.08–85.42) | 0.586 |
| A_G_C | 179 (19.76) | 214 (15.53) | 1.33 (0.97–1.81) | 0.072 |
| C_A_A | 210 (23.18) | 393 (28.52) | 0.69 (0.52–0.92) | 0.012 |
| C_A_C | 46 (5.08) | 61 (4.43) | 0.88 (0.51–1.50) | 0.629 |
| C_G_A | 2 (0.22) | 4 (0.29) | 0.30 (0.04–2.37) | 0.254 |
| C_G_C | 126 (13.91) | 186 (13.50) | 0.96 (0.68–1.36) | 0.837 |
| Replication | ||||
| A_A_A | 517 (32.27) | 464 (31.22) | Ref. | |
| A_A_C | 78 (4.87) | 57 (3.84) | 1.34 (0.92–1.95) | 0.126 |
| A_G_A | 3 (0.19) | 1 (0.07) | 3.12 (0.31–30.76) | 0.329 |
| A_G_C | 269 (16.79) | 213 (14.33) | 1.19 (0.95–1.50) | 0.131 |
| C_A_A | 403 (25.16) | 444 (29.88) | 0.79 (0.65–0.96) | 0.016 |
| C_A_C | 87 (5.43) | 78 (5.25) | 1.04 (0.74–1.47) | 0.813 |
| C_G_A | 2 (0.12) | 4 (0.27) | 0.49 (0.08–2.95) | 0.437 |
| C_G_C | 243 (15.17) | 225 (15.14) | 0.97 (0.77–1.22) | 0.785 |
| Pooled | ||||
| A_A_A | 816 (32.54) | 923 (32.23) | Ref. | |
| A_A_C | 121 (4.82) | 117 (4.09) | 1.14 (0.85–1.52) | 0.394 |
| A_G_A | 4 (0.16) | 2 (0.06) | 2.83 (0.50–16.10) | 0.241 |
| A_G_C | 448 (17.86) | 427 (14.91) | 1.22 (1.02–1.45) | 0.028 |
| C_A_A | 613 (24.44) | 837 (29.22) | 0.76 (0.66–0.88) | 0.0004 |
| C_A_C | 133 (5.30) | 139 (4.85) | 1.00 (0.76–1.31) | 0.981 |
| C_G_A | 4 (0.16) | 8 (0.28) | 0.51 (0.14–1.83) | 0.301 |
| C_G_C | 369 (14.71) | 411 (14.35) | 0.93 (0.78–1.12) | 0.460 |
Significant ORs in boldface.
aAdjusted for age, gender, smoking status, pack year of smoking, asbestos exposure, lung cancer in first-degree relatives, prior history of emphysema and hay fever where appropriate.