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. Author manuscript; available in PMC: 2012 Dec 5.
Published in final edited form as: Exp Neurol. 2012 Jan 11;235(1):228–237. doi: 10.1016/j.expneurol.2012.01.003

Fig. 4.

Fig. 4

Double immunofluorescence showed a parallel increase of BACE1 and PSA-NCAM labeling in CA1 and CA3 after one month of status epilepticus. Images A and G are stained with bisbenzimide for orientation. Intense BACE1 and PSA-NCAM labeling is normally present in the mossy fiber terminal field (B–F). In the epileptic mice, increased labeling for both markers occurred in CA3 mossy fiber terminals (note particularly merged image in F) but also extended into CA1 (H–L). Bar graphs depict increased specific optical density (o.d.) of PSA-NCAM (M) and BACE1 (N) immunofluorescence in CA1 and CA3 in epileptic vs. control mice. No differences between groups for either marker were seen in parietal cortex (O). Scale bar (in A)=500 μm for A–C and G–I; bar=250 μm for the remaining images.