Fig. 8.—

Copper-regulated and stress-responsive gene networks exhibit correlated expression among strains in environments where the networks are functionally important and highly expressed. Mean network correlation was calculated by averaging the gene-specific Pearson correlations among individuals for Mac1-regulated genes (n = 7), Ace1-regulated genes (n = 5), Msn2/Msn4-regulated genes (n = 39), ESR-induced genes (n = 282), ESR-repressed genes (n = 585), and genes included in none of these categories (n = 5,075). Mean correlations are plotted across environments, with copper concentration increasing from left to right for each network.