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The ratio of nonsynonymous- to synonymous SNPs per site (pN/pS) estimated for each of the branches shown in figure 1. The results shown are using the genes with dN/dS ratio (estimated for the human–chimp orthologous pair) of (A) <0.1, (B) 0.1–0.2, (C) 0.2–0.6, and (D) >0.6. Error bars are the standard error of the mean. In (D), the differences in pN/pS ratios between any two categories were not statistically significant (Z test, P > 0.12).
