Table 2.

Correlation between p-AKT(Ser473) and p-S6(Ser240/244) expression and clinicopathological parameters

Parameter	n	High p-AKTa (n)	P	High p-S6a (n)	P
Tumor location
Pancreas	7	71% (5)	0.012b	71% (5)	0.018b
Small bowel/stomach/colon	9	22% (2)		11% (1)
Other	7	0%		14% (1)
Liver metastasis
Yes	17	29% (5)	NSb	24% (4)	NSb
No	6	33% (2)		50% (3)
Proliferation index
Ki-67 < 5%	10	20% (2)	NSb	20% (2)	NSb
Ki-67 ≥ 5%	13	38% (5)		38% (5)
Carcinoid syndrome
Yes	5	40% (2)	NSb	40% (2)	NSb
No	18	28% (5)		28% (5)
Therapeutics
Somatostatin analogs (SSAs)	7	14% (1)	NSb	14% (1)	NSb
SSAs + chemotherapy/IFN	16	38% (6)		38% (6)
p-AKT expression
Low expression	16	–		13% (2)	0.011b
High expression	7	–		71% (5)
p-S6 expression
Low expression	16	13% (2)	0.011b	–
High expression	7	71% (5)		–
PTEN expression
Low expression	0	0		0
High expression	23	30% (7)		30% (7)

Notes:

^aHigh p-AKT and p-S6 expression correspond to moderate/strong staining score;

^bFisher’s exact test was used for hypothesis-testing of the relationship between categorical variables and p-AKT or p-S6 expression.

Abbreviation: NS, nonsignificant.