Table 3.
—Prevalence of Clinical and Radiologic Features of Individuals With Typical Patterns of NSIP, UIP, HP, and Nontypical CT Scan Pattern
| Consensus CT Scan Diagnosis |
|||||
| Clinical and Radiologic Features | Probable or Definite UIP (n = 62) | Probable or Definite NSIP (n = 35) | Probable or Definite HP (n = 18) | Nontypical CT Scan Pattern (n = 160) | P Value |
| Sex, male | 46 (74) | 19 (54) | 7 (39) | 73 (46) | .003a |
| Age, y | 69.5 ± 8.4 | 69.2 ± 10.2 | 62.1 ± 17.7 | 64.1 ± 12.2 | .002b |
| PFTs (n = 239) | |||||
| FVC, % predicted | 69.7 ± 13.7 | 73.3 ± 15.2 | 65.8 ± 17.2 | 69.0 ± 17.2 | .844 |
| Dlco, % predicted | 44.5 ± 14.8 | 50.8 ± 19.2 | 49.1 ± 14.4 | 55.9 ± 21.6 | .011c |
| Grade of dyspnea (n = 236)d | .471 | ||||
| 0 | 11 (24) | 9 (29) | 3 (27) | 44 (32) | |
| 1 | 8 (17) | 4 (13) | 1 (9) | 24 (18) | |
| 2 | 3 (7) | 5 (16) | 0 (0) | 14 (10) | |
| 3 | 1 (2) | 2 (6) | 0 (0) | 7 (5) | |
| 4 | 23 (50) | 11 (26) | 7 (63) | 47 (34) | |
| CT scan findings | |||||
| Reticulation | 55 (89) | 35 (100) | 14 (78) | 129 (81) | .971 |
| GGO associated with reticulation | 58 (94) | 34 (97) | 17 (94) | 122 (76) | .135 |
| GGO | 15 (24) | 7 (20) | 12 (67) | 82 (51) | .172 |
| Honeycombing | 52 (84) | 4 (11) | 5 (28) | 31 (19) | .361 |
| Micronodules | 6 (10) | 6 (17) | 8 (44) | 41 (26) | .226 |
| Consolidation | 3 (5) | 2 (6) | 2 (11) | 17 (11) | .909 |
| Mosaic attenuation | 1 (2) | 3 (9) | 9 (50) | 17 (11) | .404 |
| Craniocaudal direction | .028e | ||||
| Diffuse distribution | 36 (58) | 19 (54) | 18 (100) | 103 (64) | |
| Lower predominance | 26 (42) | 16 (46) | 0 (0) | 44 (28) | |
| Upper predominance | 0 (0) | 0 (0) | 0 (0) | 13 (8) | |
| Middle predominance | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
| Axial direction | < .001f | ||||
| Diffuse distribution | 7 (11) | 6 (17) | 13 (72) | 62 (39) | |
| Subpleural predominance | 55 (89) | 29 (83) | 5 (28) | 102 (64) | |
| Peribronchovascular predominance | 0 (0) | 0 (0) | 0 (0) | 2 (1) | |
| Fibrotic score | 37 ± 16 | 29 ± 12 | 34 ± 22 | 27 ± 19 | .002g |
Data are presented as mean ± SD or No. (%), unless indicated otherwise. Fourteen subjects with a consensus CT scan diagnosis of either COP, sarcoidosis, or RB are not included in this table, so the total included in the table is 275. Post hoc test with Bonferroni. Dlco = diffusion capacity of the lung for carbon monoxide; PFT = pulmonary function test. See Table 1 and 2 legends for expansion of other abbreviations.
UIP vs nontypical (P = .001).
UIP vs nontypical (P = .029).
UIP vs nontypical (P = .006).
Based on American Thoracic Society score.
HP vs nontypical (P = .017).
UIP vs HP (P < .001), UIP vs nontypical (P = .01), NSIP vs HP (P < .001), HP vs nontypical (P = .009).
HP vs nontypical (P = .017).