. Author manuscript; available in PMC: 2013 Dec 1.

Published in final edited form as: Lancet Neurol. 2012 Nov 6;11(12):10.1016/S1474-4422(12)70227-2. doi: 10.1016/S1474-4422(12)70227-2

Table 2.

Estimated ages at fibrillar amyloid-β onset and plateau in PSEN1 E280A mutation carriers

	Age at onset (years)	Age at plateau (years)	R² (model goodness of fit)	Absolute sum of squares
Mean cortical	28·2 (27·3–33·4)	37·6 (35·3–40·2)	0·72	0·23
Precuneus	26·5 (26·0–27·6)	36·6 (35·2–37·4)	0·77	0·43
Basal ganglia	26·6 (25·6–27·7)	34·6 (32·8–36·3)	0·71	0·17
Frontal	27·0 (26·2–28·9)	36·2 (35·1–39·3)	0·77	0·17
Anterior cingulate	27·3 (26·3–30·7)	37·4 (36·3–41·3)	0·79	0·35
Parietal	27·9 (26·7–36·2)	35·0 (33·7–41·3)	0·55	0·44
Temporal	28·8 (27·5–33·1)	37·1 (36·0–41·3)	0·70	0·23
Posterior cingulate	29·0 (26·0–32·1)	38·2 (36·2–41·3)	0·70	0·37

Data are mean (95% CI).