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. Author manuscript; available in PMC: 2012 Dec 5.
Published in final edited form as: Sci Signal. 2012 Apr 3;5(218):ra26. doi: 10.1126/scisignal.2002334

Fig. 3.

Fig. 3

Astrocytic calcium transients contribute to K+ clearance in response to moderate, but not pathophysiological, changes in extracellular K+ in cultured astrocytes and in hippocampal slices. (A) Bar graph illustrating the calcium dependence of ouabain-sensitive 86Rb+ uptake in cultured astrocytes to physiological and pathophysiological changes in extracellular K+ concentration (n = 4 slices). *P < 0.05, t test. (B) HFS-induced changes in extracellular K+ in wild-type (IP3R2+/+) and IP3R2−/− mice. Dashed line indicates baseline K+ concentration. (C) Bar graphs comparing relative increase in Ca2+ (rhod-2 signal, n = 12 slices, ΔF/F, left panel) and changes in extracellular K+ (peak increase and undershoot) in IP3R2+/+ and IP3R2−/− mice (right panel, n = 7 slices). **P < 0.01, t test.