Table 4. MAGENTA Significant categories of genes with nominal p-value<0.05 in the OZALC-NAG and the SAGE studies and ARIC corresponding results.

			OZALC-NAG	SAGE	ARIC	Combined
Threshold	Acc	Name	p-value	p-value	p-value	p-value *
0.005	GO:0035095	behavioral response to nicotine	2.20E−03	2.20E−03	2.00E−03	8.29E−06
	GO:0060084	synaptic transmission involved in micturition	8.50E−03	7.20E−03	7.90E−03	1.91E−04
0.01	GO:0006942	regulation of striated muscle contraction	6.50E−03	6.30E−03	1.00E+00	2.94E−01
0.05	GO:0004889	nicotinic acetylcholine-activated cation-selective channel activity	8.50E−05	4.06E−02	6.00E−04	7.83E−07
	GO:0005892	nicotinic acetylcholine-gated receptor-channel complex	8.20E−05	4.36E−02	1.10E−03	1.60E−06
	GO:0015464	acetylcholine receptor activity	2.68E−04	2.50E−02	2.20E−03	5.90E−06
	GO:0005230	extracellular ligand-gated ion channel activity	3.50E−03	1.65E−02	1.76E−02	3.43E−04
	GO:0007271	synaptic transmission, cholinergic	3.30E−03	2.63E−02	2.60E−02	6.41E−04
	GO:0042060	wound healing	3.00E−04	1.69E−02	3.22E−01	6.05E−03
	GO:0006940	regulation of smooth muscle contraction	2.50E−02	2.61E−02	1.33E−01	1.68E−02
	GO:0005216	ion channel activity	2.52E−02	1.53E−02	1.88E−01	2.23E−02
	GO:0042552	myelination	1.51E−02	1.64E−02	4.35E−01	5.94E−02
	GO:0007257	activation of JUN kinase activity	3.42E−02	3.61E−02	3.52E−01	7.47E−02
	GO:0006548	histidine catabolic process	4.71E−02	4.27E−02	3.04E−01	7.52E−02
	GO:0034185	apolipoprotein binding	4.20E−02	4.12E−02	1.00E+00	1.45E−01
	GO:0007265	Ras protein signal transduction	4.17E−02	4.99E−02	8.33E−01	3.14E−01

Threshold of significance satisfied by both NAF and SAGE; acc: identifier for the category of genes and name. For each study, the nominal GSEA p-value is shown (see Table S4 for false discovery rate).

^*Combined p-values were calculated employing the weighted Z-score method.