Table 5.
Comparisons of patients with mMRC = 0 and patients with mMRC ≥ 1 concerning clinical characteristics, lung function and biological parameters
| MRC = 0 (n = 7) | MRC ≥ 1 (n = 38) | |
|---|---|---|
|
Demographic characteristics |
|
|
| Age |
50 ± 10 |
51 ± 11 |
| Sex (M/F) |
4/3 |
13/25 |
|
BMI (kg/m2) |
36 ± 5 |
44 ± 9* |
|
Smoking history |
|
|
| Pack-years |
10 ± 16 |
10 ± 17 |
|
PFTs |
|
|
| FEV1,% pred |
101 ± 16 |
86 ± 17* |
| VC,% pred |
103 ± 15 |
90 ± 20 |
| FEV1/VC |
0.78 ± 0.05 |
0.77 ± 0.11 |
| FRC,% pred |
100 ± 16 |
91 ± 25 |
| ERV,% pred |
91 ± 32 |
50 ± 31** |
| TLC,% pred |
101 ± 11 |
97 ± 17 |
| DLCO,% pred |
86 ± 18 |
83 ± 19 |
|
Arterial blood gases |
|
|
| PaO2 (mmHg) |
99 ± 24 |
88 ± 14 |
| PaCO2 (mmHg) |
39 ± 4 |
39 ± 4 |
|
6-minute walk test |
|
|
| 6-minute walk distance (m) |
524 ± 72 |
401 ± 107** |
| SpO2 at rest (%) |
98 ± 2 |
97 ± 2 |
| SpO2 after exertion (%) |
94 ± 2 |
96 ± 2 |
| Borg score at res |
0.1 ± 0.4 |
1.1 ± 1.6 |
| Borg score after 6MWT |
3.9 ± 3 |
5.7 ± 2.1 |
|
Biological parameters |
|
|
| Hemoglobin (g/dL) |
14.8 ± 1,3 |
13.7 ± 1,5* |
| NT pro-BNP (pg/mL) |
97 ± 199 |
121 ± 301 |
| CRP (mg/L) |
5 ± 4,9 |
9.1 ± 7,4 |
| Triglyceride (mmol/L) |
1.9 ± 0,9 |
1.5 ± 0,8 |
| Total cholesterol (mmol/L) |
5.4 ± 1 |
4.7 ± 1 |
| Fasting glucose (mmol/L) |
5.3 ± 0,8 |
7.8 ± 3,3 |
| Hba1c (%) | 5.7 ± 0,6 | 6.8 ± 1,6 |
Data are expressed as number (%) or mean ± SD; *p value < 0.05, **p value < 0.01.
FEV1: expiratory volume in one second, pred: predicted value, VC: vital capacity, FRC: functional residual capacity, ERV: expiratory reserve volume, TLC: total lung capacity, DLCO: carbon monoxide diffusing capacity of the lung, NT pro-BNP: N-terminal pro brain natriuretic peptide, CRP: serum C reactive protein, HbA1c: glycated hemoglobin.
Normal biological parameters values were based on the normal values for our laboratory: fasting glucose: 3.3 to 6.1 mmol/L; HbA1c: 4 to 6%; total cholesterol: 3 to 5.2 mmol/L; triglycerides: 0.3 to 1.7 mmol/L; NT-pro BNP < 300 pg/mL; CRP < 10 mg/L. Anemia was defined as hemoglobin level < 13 g/dL in men and 12 g/dL in women.