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. 2012 Dec 5;7(12):e50802. doi: 10.1371/journal.pone.0050802

Figure 3. Remodeling of the extracellular matrix after nine weeks of pressure overload.

Figure 3

(A) Representative pictures of collagen staining (Sirius Red) suggest a higher overall collagen content in placebo and raloxifene treated mice compared to E2 and 16α-LE2 treated animals. (B) Quantification of fibrosis score showed a significantly lower level of collagen in mice with E2 and ERα agonist; ANOVA post-hoc Scheffé; p-value p<0.05 (C) Comparable with the collagen content connective tissue growth factor (CTGF) gene expression was significantly lower in mice with E2 or 16α-LE2; ANOVA post-hoc Scheffé; p-value p<0.05.