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. 2012 Dec 5;7(12):e51044. doi: 10.1371/journal.pone.0051044

Figure 6. Arr-HSC cell spreading is impaired in the presence of a function-blocking antibody to α1 integrin. A.

Figure 6

The impedance, reflecting cell adhesion and spreading, was measured for Ctrl-HSC and Arr-HSC cells using electric cell-substrate impedance sensing (ECIS) (mean of duplicate wells of representative ECIS plates). The Arr-HSC cells showed markedly higher impedance at a low frequency than the control cells. B. Treatment of Arr-HSC cells with a specific function-blocking α1 antibody reduced the impedance when compared to the untreated Arr-HSC cells. Treatment of Arr-HSC cells with integrin α2 antibody almost completely abolished the cell spreading. C. Ctrl-HSC cells showed reduced spreading in the presence of integrin α2 antibody while α1 antibody had no effect on impedance.