Table 2. Univariate and multivariate cox-regression model for overall survival time analysis.
| Univariate | Multivariate | |||
| Variables | HR (95%CI.) | P-value | HR (95%CI.) | P-value |
| YKL-40 intratumoral staining | ||||
| Negative | Reference | Reference | ||
| Positive | 3.46 (1.15–10.39) | 0.027 | 1.60 (0.40–6.34) | 0.504 |
| YKL-40 serum level | 1.05 (1.03–1.07) | <0.001* | 1.04 (1.02–1.06) | <0.001* |
| Age | ||||
| ≦40 years | Reference | NA | ||
| 40 to 60 years | 1.80 (0.73–4.43) | 0.203 | ||
| ≧60 years | 2.02 (0.59–6.89) | 0.261 | ||
| Tumor size, cm | ||||
| ≦2 cm | Reference | |||
| >2 cm | 3.79 (1.52–9.44) | 0.004* | 3.74 (0.71–19.68) | 0.120 |
| Pathological classification | ||||
| noninvasive ductal carcinoma | Reference | Reference | ||
| Invasive lobular carcinoma | 2.25 (0.75–6.73) | 0.147 | 1.99 (0.41–9.65) | 0.391 |
| invasive ductal carcinoma | 3.64 (1.26–10.51) | 0.017* | 2.07 (0.43–9.87) | 0.363 |
| TNM stage | ||||
| I | Reference | |||
| II | 1.99 (0.62–6.45) | 0.249 | 0 (0–3.08×1096) | 0.923 |
| III | 16.45 (4.32–62.62) | <0.001* | 0 (0–4.88×1096) | 0.926 |
| Lymph node metastasis | ||||
| Negative | Reference | Reference | ||
| Positive | 5.08 (1.72–14.95) | 0.003* | 0.6×106 (0–1.92×106) | 0.926 |
| ER | ||||
| Negative | Reference | NA | ||
| Positive | 0.65 (0.27–1.54) | 0.324 | ||
| PR | ||||
| Negative | Reference | NA | ||
| Positive | 1.01 (0.43–2.40) | 0.981 | ||
Results were presents as estimated Hazard Ratio with 95% confidence interval (HR (95%CI.)) for specific variables.
Variables with a significant P-value (<0.05) in univariate cox-regression model were selected and analyzed by using multivariate cox-regression model.
NA, not assessed.
*
P<0.05, indicated a significant association.