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. 2012 Dec 5;7(12):e49077. doi: 10.1371/journal.pone.0049077

Figure 5. Increased expression of miR-499 in diabetic cardiomyopathy (DCM) and the effect of miR-499 on the expression of Gadd45α.

Figure 5

(A) MiRNAs with significantly different expression (P<0.05) in DCM detecting by miR microarray (n = 3). (B) The expression of miR-499 was increased in diabetic heart and nucleus ambiguous (NA). *P<0.05 vs Ctl. (C) Complementarity between miR-499 and Gadd45α. (D) Suppression of miR-499 on the translation of Gadd45α by luciferase assay. The mRNA (E) and protein (F) expression of Gadd45α in miR-499 treated neonatal cardiac myocytes. *P<0.05 vs Negative control (NC). **P<0.01 vs NC; # P<0.05 vs miR-499; ##P<0.01 vs miR-499. Values are means of 6 independent experiments, with standard errors represented by vertical bars.