Table 1. The analyzed tag SNPs, the genotype frequencies and the p-values for the association tests using linear regression.
GHRL | ||||||
rs26802 | TT | GT | GG | β | P | Pcorrected |
Total sample | 165 | 126 | 23 | −1,15 | 0,230 | 0,897 |
Male subsample | 64 | 51 | 9 | 1,29 | 0,405 | |
Female subsample | 101 | 75 | 14 | −2,71 | 0,026* | |
rs4684677 | TT | AT | AA | β | P | Pcorrected |
Total sample | 267 | 39 | 1 | −1,97 | 0,259 | 0,926 |
Male subsample | 110 | 13 | 0 | −5,97 | 0,053 | |
Female subsample | 157 | 26 | 1 | −0,42 | 0,842 | |
rs42451 | CC | CT | TT | β | P | Pcorrected |
Total sample | 185 | 110 | 15 | 0,02 | 0,988 | 1,000 |
Male subsample | 72 | 44 | 6 | 2,59 | 0,119 | |
Female subsample | 113 | 66 | 9 | −1,65 | 0,217 | |
rs35680 | TT | CT | CC | β | P | Pcorrected |
Total sample | 82 | 146 | 72 | −0,52 | 0,545 | 1,000 |
Male subsample | 29 | 62 | 28 | −1,86 | 0,191 | |
Female subsample | 53 | 84 | 44 | 0,31 | 0,772 | |
rs34911341 | CC | CT | TT | β | P | Pcorrected |
Total sample | 314 | 3 | 0 | 8,30 | 0,180 | 0,829 |
Male subsample | 124 | 1 | 0 | 7,93 | 0,463 | |
Female subsample | 190 | 2 | 0 | 8,33 | 0,270 | |
rs 696217 | GG | GT | TT | β | P | Pcorrected |
Total sample | 254 | 58 | 4 | 1,42 | 0,300 | 0,955 |
Male subsample | 97 | 26 | 1 | 0,25 | 0,908 | |
Female subsample | 157 | 32 | 3 | 2,28 | 0,194 | |
GHSR | ||||||
rs2948694 | AA | AG | GG | β | P | Pcorrected |
Total sample | 251 | 58 | 6 | −4,11 | 0,002* | 0,015* |
Male subsample | 105 | 17 | 3 | −6,22 | 0,003* | |
Female subsample | 146 | 41 | 3 | −3,07 | 0,062 | |
rs572169 | CC | CT | TT | β | P | Pcorrected |
Total sample | 140 | 143 | 32 | −0,02 | 0,979 | 1,000 |
Male subsample | 48 | 61 | 16 | 0,56 | 0,697 | |
Female subsample | 92 | 82 | 16 | −0,22 | 0,855 | |
rs2232165 | GG | AG | AA | β | P | Pcorrected |
Total sample | 289 | 21 | 1 | −2,73 | 0,219 | 0,887 |
Male subsample | 114 | 7 | 1 | 0,60 | 0,860 | |
Female subsample | 175 | 14 | 0 | −5,38 | 0,068 | |
rs495225 | AA | AG | GG | β | P | Pcorrected |
Total sample | 151 | 129 | 32 | −2,00 | 0,026* | 0,215 |
Male subsample | 65 | 42 | 13 | −0,24 | 0,862 | |
Female subsample | 86 | 87 | 19 | −3,34 | 0,004* |
GHRL, pro-ghrelin gene; GHSR, growth hormone secretagogue receptor gene; β, β-value describing the slope of the curve in the linear regression model; p, p-value using linear regression; pcorrected, p-value corrected for multiple testing using permutation test.