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. 2012 Dec 5;7(12):e50265. doi: 10.1371/journal.pone.0050265

Figure 5. Prolonged functionality of encapsulated islets in vivo.

Figure 5

Pancreatic islets from DBA/2 mice were grafted under the kidney capsule of C57BL/6 recipients: the islets were either untreated (Ctrl); or encapsulated in PEG alone (PEG alone); or with PEG decorated with empty nanoparticles (PEG+Empty Nano); or with PEG decorated with LIF-containing nanoparticles (PEG+LIF-Nano). The ability of these grafts to support normoglycemia over 100 d is shown as “% survival” in (A). Histology of grafts taken from recipients showing normoglycemia at 100 d revealed well-preserved β cells containing insulin, as illustrated in (B).