Table 3. Pair-wise linkage disequilibrium of the three tag SNPs in Sherpa, non-Sherpa Nepalese, J-HAPE-s, and J-HAPE-r populations.* .
SNP1 | SNP2 | D' | r2 | LOD |
Sherpas | ||||
rs13419896 | rs4953354 | 0.64 | 0.323 | 8.54 |
rs13419896 | rs4953388 | 0.868 | 0.529 | 15.75 |
rs4953354 | rs4953388 | 0.918 | 0.458 | 13.6 |
non-Sherpa Nepalese | ||||
rs13419896 | rs4953354 | 0.179 | 0.018 | 0.58 |
rs13419896 | rs4953388 | 0.043 | 0.002 | 0.04 |
rs4953354 | rs4953388 | 0.105 | 0.007 | 0.15 |
J-HAPE-s | ||||
rs13419896 | rs4953354 | 0.487 | 0.116 | 1 |
rs13419896 | rs4953388 | 1 | 0.01 | 0.4 |
rs4953354 | rs4953388 | 1 | 0.005 | 0.21 |
J-HAPE-r | ||||
rs13419896 | rs4953354 | 0.482 | 0.078 | 0.92 |
rs13419896 | rs4953388 | 0.053 | 0 | 0 |
rs4953354 | rs4953388 | 0.017 | 0 | 0 |
Abbreviations: LOD, logarithm of the odds; J-HAPE-r, Japanese high-altitude pulmonary edema-resistant subjects; J-HAPE-s, Japanese high-altitude pulmonary edema-susceptible subjects, SNP, single nucleotide polymorphism.
D’ values, r2 values, and LOD were examined with Haploview 3.32.