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Dominant negative phospholipase D1 and D2 constructs inhibit PTH-stimulated transphosphatidylation (A) and hydrolysis of ethanolamine-containing phospholipids (B) and phosphatidylcholine (C) in UMR-106 cells. Incubation time was 30 minutes. Results in figure A are the mean and SE of duplicate measurements for each treatment. Results in figures B and C are the mean and SE of triplicate determinations for each treatment. ***p<0.001 vs. pcDNA3; +++p<0.001 vs. PTH.
