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. Author manuscript; available in PMC: 2012 Dec 5.
Published in final edited form as: ChemMedChem. 2011 Apr 28;6(6):1024–1040. doi: 10.1002/cmdc.201100010

Scheme 1. Synthesis of 9.

Scheme 1

Reagents and conditions: (a) ethyl acetoacetate, H2SO4, 25%; (b) BnBr, K2CO3, DMF, 85%; (c) SeO2, xylenes, 150 °C, 12h, 61%; (d) BnNH2, NaBH3CN, 50-80%; (e) BnBr, K2CO3, DMF, 100 °C, 90%; (f) DiBAlH, CH2Cl2, −78 °C, 72%.