Fig. 1.

Utility of genetically engineered mouse models in the development of therapeutics. Knowledge of genetic abnormalities (mutations or pathway aberrations) and transcriptional signatures in human medulloblastoma and hypotheses regarding the cell of origin can be used to develop mouse models of the disease. Depicted are some of the current mouse models available and which human medulloblastoma subgroups they represent. Mouse models can be used to study tumor biology, and cells isolated from these models can be used for high-throughput or candidate screening to identify novel approaches to therapy. Mouse models can also be used to test the efficacy of these therapies in vivo. Subgroup-specific therapies can be translated back to the clinic to improve treatment strategies for patients