Table 4.1.

Relative efficiencies of DC-mediated HIV-1 uptake, viral replication, and transmission of HIV-1 to CD4⁺ T cells

Maturation stimulus	HIV-1 uptake	Productive HIV-1 infection	Transmission of HIV-1 to target CD4+ T cells	References
None (immature DCs)	+	++	+	Dong et al. (2007) and Wang et al. (2007b)
LPS	++++	−	+++	Dong et al. (2007), Pertel et al. (2011) and Sanders et al. (2002)
PolyI:C	n/a	n/a	++++	Sanders et al. (2002)
IFNα	++	−	+	Coleman et al. (2011) and Pertel et al. (2011)
TNFα	+	++	++	Dong et al. (2007)
CD40L	+	+++	++++	Dong et al. (2007) and Sanders et al. (2002)

In these experiments, immature DCs were treated with the maturation stimuli for 24–48 h and infected with HIV-1 or HIV-1 cell-to-cell transmission assays were performed as described in the noted references. Relative efficiencies of HIV-1 infection and transmission are scored with a “+”; restricted HIV-1 infection is indicated by a “−.” n/a = not assessed in current literature. LPS lipopolysaccharide, IFNα interferon-α, CD40L CD40 ligand, TNF-α tumor necrosis factor α