Figure 2. Effects of the GlyT-1 inhibitor ALX-5407 on EtOH-induced ataxia and LORR duration.
Treatment with ALX-5407 did not alter EtOH-induced rotarod ataxia in B6 (A) or S1 (B) mice (n=7–11/dose/strain). The highest dose of ALX-5407 potentiated (3.5 g/kg) EtOH-induced LORR duration in B6 (C) and S1 (D) mice (n=8–14/dose/strain). Data are means ±SEM. *p<.05 vs. 0 mg/kg
