Table 5. Effects of Mg depletion on EtOH-related behaviors.
In B6 mice, dietary depletion of Mg significantly increased EtOH-induced LORR duration relative to control diet, but did not significantly affect EtOH-induced ataxia or EtOH-induced hypothermia (n=13–15/treatment). In S1 mice, dietary depletion of Mg did not significantly affect any measure of EtOH intoxication, but approximately 75% of S1 mice died as a result of Mg treatment (n=4–16/treatment).
| B6 | S1 | |||
|---|---|---|---|---|
| Control diet | Mg deficient diet | Control diet | Mg deficient diet | |
| Ataxia | 69.6 ±7.0 | 58.5 ±11.3 | 66.1 ±6.1 | 39.3 ±16.1 |
| Hypothermia | 2.8 ±0.3 | 2.5 ±0.4 | 3.9 ±0.2 | 3.7 ±0.3 |
| LORR duration | 66.9 ±10.2 | * 97.4 ±9.5 | 179.8 ±9.8 | 126.0 ±35.4 |
Data are Means ±SEM.
p<.05 vs. Control diet