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. Author manuscript; available in PMC: 2012 Dec 6.
Published in final edited form as: Horm Behav. 2005 Jun 16;49(1):45–67. doi: 10.1016/j.yhbeh.2005.05.003

Figure 1. Meta-analysis of the effect of Vorozole™ on consummatory sexual behavior evaluated by the measure of CCM latency in the small arena.

Figure 1

Each line represents one experiment identified by the name of the group (I: intact; CX+T40 or CX+T20: castrated plus 40 or 20 mm testosterone) followed by the number of the experiment. Average values (± SD) of results in both groups are also presented, followed by the effect size, number of observations and probability associated with the difference (calculated by t test). Since all subjects were tested in both conditions and used as their own control, this number is equal to the double of the number of subjects.

The right-hand column is a tree representation of the effect size associated with the experiment. For each experiment, a point estimate (indicated by a tick) represents the measured effect expressed as a value, namely the effect size, comparable to the effects observed in the other experiments. The horizontal bar surrounding the point estimate represents the confidence interval associated to the effect size. A point estimate of 0.00 indicates no effect. Values higher than 0.00 reflect an effect in the predicted direction (See methods for more details on the sign assignment), while values smaller than 0.00 reflect an effect in the opposite direction. The distance to 0.00 indicates the amplitude of the effect-size. If the point estimate and confidence interval fall below 0.00 the experiment would meet the criterion for statistical significance (p-value ≤ 0.05). On the contrary, if the confidence interval overlaps 0.00, the p-value would exceed 0.05 and the experiment would not be statistically significant. Some lines do not have ticks. This is due to the fact that these estimate points fall out of the scale used to present these data.

The “random” line (in bold) represents the summary of random-effects estimate for the combination of experiments performed in similar conditions of dose and timing. Data provided are from left to right: the effect size, total number of observations and associated probabilities. The two combined lines at the bottom represent the combination of all experiments (Vor - 6 and 30 mg/kg) or the combination of experiments testing only the effects of the higher dose (Vor -30 mg/kg). Values in the positive side represent an inhibitory effect on behavior (increase of the latency of CCM) while values in the negative side indicate a decrease of the CCM latency.