Table 4.
Five most significant up-regulated (bold) and down-regulated (italic) biological pathways in common in HAND and AD or MS and ART-HAND and AD or MS
| Alzheimer’s disease | Multiple sclerosis | |||
|---|---|---|---|---|
| Gene category | EASE score | Gene category | EASE score | |
| HAND | immune response | 1.36E-30 | response to external stimulus | 4.97E-07 |
| defense response | 2.25E-28 | immune response | 2.83E-06 | |
| response to biotic stimulus | 3.10E-28 | response to biotic stimulus | 3.63E-06 | |
| response to external stimulus | 2.82E-23 | defense response | 1.33E-05 | |
| antigen presentation | 5.30E-19 | response to stress | 0.0007 | |
| transmission of nerve impulse | 3.48E-12 | calmodulin-dependent protein kinase Iactivity | 0.010 | |
| synaptic transmission | 1.43E-11 | non-kinase phorbol ester receptoractivity | 0.013 | |
| transport | 1.15E-10 | calcium/calmodulin-dependent kinase activity | 0.033 | |
| cell-cell signaling | 2.91E-10 | calmodulin binding | 0.045 | |
| synaptic vesicle | 7.59E-10 | phorbol ester receptor activity | 0.046 | |
| ART-HAND | antigen presentation | 1.20E-05 | immune response | 0.002 |
| antigen processing | 1.20E-05 | defense response | 0.003 | |
| signal transducer activity | 7.17E-05 | response to biotic stimulus | 0.005 | |
| immune response | 0.0002 | response to external stimulus | 0.021 | |
| defense response | 0.0004 | antigen processing | 0.022 | |
| DNA helicase activity | 0.018 | intracellular signaling cascade | 0.005 | |
| hydrolase activity | 0.025 | signal transduction | 0.012 | |
| cell growth and/or maintenance | 0.036 | catalytic activity | 0.015 | |
| binding | 0.038 | cell communication | 0.038 | |
| cellular process | 0.045 | |||