Table 3.

Non-hematological toxicity of grades 3 and 4 – relative frequency of adverse events

	EC-Doc, %	FEC, %	p value
Elevation of liver enzymes grade 3/4
Bilirubin/transaminases	1.2/1.4	0.3/1.9	0.11/0.52
Gastrointestinal symptoms grade 3/4
Nausea/vomiting	5.1/6.2	4.7/2.8	0.7/0.003
Diarrhea	2.7	2.3	0.7
Mucositis	8.9	8.7	0.9
Cardiac symptoms grade 3/4	0.3	1.1	0.10
Edema	2.6	0.3	< 0.001
Neurological symptoms grade 3/4	3.9	0.3	< 0.001
Dermatologic symptoms grade 3/4	4.2	0.8	< 0.001
Allergy grade 3/4	0.5	0	0.25
Fever	1.1	0.8	0.8
Pain in general grade 3/4	14.2	3.6	< 0.001
Arthralgia, myalgia grade 3/4	12.3	1.4	0.001