Figure 6. Cardiac activation of IGF-2R induced cardiomyocyte hypertrophy is mediated by the Gαs signalling pathway in normally grown fetuses.

No change in the amount of PKAα/β/γ catalytic subunits (A) was observed in control and Leu²⁷IGF-2-infused fetuses. There were increased amounts of left ventricle phospho-PKAα/β/γ catalytic subunits (B), CREB (C) and phospho-CREB (D) in Leu²⁷IGF-2-infused fetuses. Representative blots from 3 animals in each group for each protein. Sample size for each group is indicated in the bar. *Significantly different from control fetuses (P < 0.05).