Table 2.
Mean arterial blood pressure, heart rate and rate pressure product over a 20 min period on each day of the experimental protocol in control and Leu27IGF-2-infused sheep fetuses
| Day of infusion | |||||||
|---|---|---|---|---|---|---|---|
| –1 day | 0 day (prior to infusion) | +1 days | +2 days | +3 days | +4 days | ||
| SBP (mmHg) | Control | 44.7 ± 4.7 (8) | 42.5 ± 2.6 (11) | 41.7 ± 3.9 (12) | 38.9 ± 2.8 (12) | 39.2 ± 2.5 (13) | 39.8 ± 3.3 (9) |
| Leu27IGF-2 | 44.9 ± 4.3 (8) | 47.0 ± 3.6 (9) | 49.6 ± 3.2 (8) | 49.5 ± 2.9 (8) | 50.9 ± 3.7 (8) | 48.9 ± 3.3 (9) | |
| DBP (mmHg) | Control | 30.0 ± 2.7 (8) | 29.8 ± 1.6 (11) | 29.2 ± 2.2 (12) | 28.7 ± 2.0 (12) | 29.8 ± 1.7 (13) | 32.2 ± 3.0 (9) |
| Leu27IGF-2 | 31.6 ± 3.6 (8) | 32.5 ± 3.3 (9) | 34.8 ± 3.4 (8) | 36.5 ± 3.2 (8) | 38.0 ± 3.6 (8) | 36.7 ± 2.9 (9) | |
| MAP (mmHg) | Control | 35.9 ± 3.4 (8) | 34.8 ± 1.9 (11) | 34.2 ± 2.9 (12) | 32.8 ± 2.2 (12) | 33.6 ± 1.9 (13) | 35.3 ± 3.1 (9) |
| Leu27IGF-2 | 36.9 ± 3.8 (8) | 36.7 ± 3.7 (9) | 40.7 ± 3.2 (8) | 41.7 ± 3.0 (8) | 43.2 ± 3.2 (8) | 41.6 ± 3.0 (9) | |
| HR (beats min−1) | Control | 168.3 ± 3.8 (8) | 172.8 ± 4.6 (11) | 171.2 ± 4.0 (12) | 171.8 ± 3.9 (12) | 172.5 ± 2.6 (13) | 167.4 ± 4.0 (9) |
| Leu27IGF-2 | 179.5 ± 6.7 (8) | 180.5 ± 4.4 (9) | 176.7 ± 3.9 (8) | 174.9 ± 4.0 (8) | 170.3 ± 3.5 (8) | 159.9 ± 2.2 (9) | |
| RPP (mmHg× | Control | 7504.6 ± 775.5 (8) | 7302.6 ± 435.4 (11) | 7126.7 ± 664.1 (12) | 6651.2 ± 468.5 (12) | 6756.5 ± 427.5 (13) | 6706.6 ± 670.9 (9) |
| beats min−1) | Leu27IGF-2 | 8149.4 ± 921.7 (8) | 8493.7 ± 680.7 (9) | 8774.1 ± 605.1 (8) | 8698.4 ± 626.2 (8) | 8668.3 ± 638.2 (8) | 7826.6 ± 558.3 (9) |
Values are mean ± SEM (n). SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; HR, heart rate; RPP, rate pressure product.